Mixing Aβ(1-40) and Aβ(1-42) peptides generates unique amyloid fibrils
Authors list
Linda Cerofolini Enrico Ravera Sara Bologna Thomas Wiglenda Annett Böddrich Bettina Purfürst Iryna Benilova Magdalena Korsak Gianluca Gallo Domenico Rizzo Leonardo Gonnelli Marco Fragai Bart De Strooper Erich E Wanker Claudio LuchinatAbstract
Recent structural studies show distinct morphologies for the fibrils of Aβ(1-42) and Aβ(1-40), which are believed not to co-fibrillize. We describe here a novel, structurally-uniform 1 : 1 mixed fibrillar species, which differs from both pure fibrils. It forms preferentially even when Aβ(1-42) : Aβ(1-40) peptides are mixed in a non-stoichiometric ratio.
Journal details
Journal Chemical Communications
Volume 56
Issue number 62
Pages 8830-8833
Available online
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Publisher website (DOI) 10.1039/d0cc02463e
Europe PubMed Central 32749391
Pubmed 32749391
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