Modelling intestinal inflammation and infection using 'mini-gut' organoids


In 2020, major advances to the understanding of gastrointestinal inflammatory and infectious disease have been made using ‘mini-gut’ organoids. Key findings include the discovery of somatic inflammatory gene mutations in ulcerative colitis epithelium, a unique mutational signature in colorectal cancer caused by genotoxic , and infection of intestinal organoids by SARS-CoV-2.

Journal details

Volume 18
Issue number 2
Pages 89-90
Available online
Publication date