Modelling intestinal inflammation and infection using 'mini-gut' organoids
Abstract
In 2020, major advances to the understanding of gastrointestinal inflammatory and infectious disease have been made using ‘mini-gut’ organoids. Key findings include the discovery of somatic inflammatory gene mutations in ulcerative colitis epithelium, a unique mutational signature in colorectal cancer caused by genotoxic , and infection of intestinal organoids by SARS-CoV-2.
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Volume 18
Issue number 2
Pages 89-90
Available online
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Publisher website (DOI) 10.1038/s41575-020-00391-4
Europe PubMed Central 33257835
Pubmed 33257835
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