Molecular definitions of autophagy and related processesMore about Open Access at the Crick
Authors listLorenzo Galluzzi Eric H Baehrecke Andrea Ballabio Patricia Boya José Manuel Bravo-San Pedro Francesco Cecconi Augustine M Choi Charleen T Chu Patrice Codogno Maria Isabel Colombo Ana Maria Cuervo Jayanta Debnath Vojo Deretic Ivan Dikic Eeva-Liisa Eskelinen Gian Maria Fimia Simone Fulda David A Gewirtz Douglas R Green Malene Hansen J Wade Harper Marja Jäättelä Terje Johansen Gabor Juhasz Alec C Kimmelman Claudine Kraft Nicholas T Ktistakis Sharad Kumar Beth Levine Carlos Lopez-Otin Frank Madeo Sascha Martens Jennifer Martinez Alicia Melendez Noboru Mizushima Christian Münz Leon O Murphy Josef M Penninger Mauro Piacentini Fulvio Reggiori David C Rubinsztein Kevin M Ryan Laura Santambrogio Luca Scorrano Anna Katharina Simon Hans-Uwe Simon Anne Simonsen Nektarios Tavernarakis Sharon Tooze Tamotsu Yoshimori Junying Yuan Zhenyu Yue Qing Zhong Guido Kroemer
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Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear that autophagy and autophagy-related processes have profound implications for human pathophysiology. However, considerable confusion persists about the use of appropriate terms to indicate specific types of autophagy and some components of the autophagy machinery, which may have detrimental effects on the expansion of the field. Driven by the overt recognition of such a potential obstacle, a panel of leading experts in the field attempts here to define several autophagy-related terms based on specific biochemical features. The ultimate objective of this collaborative exchange is to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagy research.
Journal EMBO Journal
Issue number 13