Multiple risk factors for persistent HBV viraemia in an adult receiving nucleos/tide analogue therapy
Authors list
Sheila Lumley Maeve Barlow Khadija Said Emily Martyn Elizabeth Waddilove Marion Delphin Daisy Jennings Haiting Chai Agnes Kemper Joy Ko Azim Ansari Douglas Macdonald Indrajit Ghosh Samreen Ijaz Stuart Flanagan Philippa MatthewsAbstract
Diagnosing and treating chronic hepatitis B virus (HBV) infection are key interventions to support progress towards elimination of viral hepatitis by 2030. Although nucleos/tide analogue (NA) therapy is typically highly effective, challenges remain for viral load (VL) suppression, including medication access, incomplete adherence and drug resistance. We present a case of a long-term HBV and HIV coinfected adult prescribed with sequential NA therapy regimens, with episodes of breakthrough viraemia. Multiple factors contribute to virological breakthrough, including exposure to old NA agents, initial high HBV VL, therapy interruptions, intercurrent illnesses and potential contribution from resistance mutations. The case underscores the importance of individualised treatment approaches and adherence support in achieving HBV suppression. Furthermore, it emphasises the need for improved clinical pathways addressing education, support and access to care, particularly for marginalised populations. Comprehensive data collection inclusive of under-represented individuals is crucial for maintaining retention in the care cascade and informing effective interventions.
Journal details
Journal
Sexually Transmitted Infections
Volume
100
Issue number
5
Pages
329-331
Available online
Publication date
Full text links
Publisher website (DOI)
10.1136/sextrans-2024-056168
Europe PubMed Central
38914475
Pubmed
38914475
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