Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate
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Alexandre Gouzy Gérald Larrouy-Maumus Ting-Di Wu Antonio Peixoto Florence Levillain Geanncarlo Lugo-Villarino Jean-Luc Guerquin-Kern Luiz Pedro Carvalho Yannick Poquet Olivier NeyrollesAbstract
Here we identify the amino acid transporter AnsP1 as the unique aspartate importer in the human pathogen Mycobacterium tuberculosis. Metabolomic analysis of a mutant with an inactive AnsP1 revealed that the transporter is essential for M. tuberculosis to assimilate nitrogen from aspartate. Virulence of the AnsP1 mutant is impaired in vivo, revealing that aspartate is a primary nitrogen source required for host colonization by the tuberculosis bacillus.
Journal details
Journal Nature Chemical Biology
Volume 9
Issue number 11
Pages 674-676
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Publisher website (DOI) 10.1038/nchembio.1355
Europe PubMed Central 24077180
Pubmed 24077180
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