Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

More about Open Access at the Crick

Abstract

Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mouse model of influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by amines to inhibit pDC. Our study establishes a functional link between natural amines and the innate immune system and identifies CXCR4 as a potential 'on-off' switch of pDC activity with therapeutic potential.

Journal details

Volume 8
Pages 14253
Available online
Publication date

Crick authors

Crick First author
Crick Corresponding author