Neoadjuvant chemotherapy modulates the immune microenvironment in metastases of tubo-ovarian high-grade serous carcinoma

Authors list

Steffen Böhm Anne Montfort Oliver MT Pearce Joanne Topping Probir Chakravarty Gemma LA Everitt Andrew Clear Jackie R McDermott Darren Ennis Thomas Dowe Amanda Fitzpatrick Elly C Brockbank Alexandra C Lawrence Arjun Jeyarajah Asma Z Faruqi Iain A McNeish Naveena Singh Michelle Lockley Frances R Balkwill

Abstract

The purpose of this study was to assess the effect of neoadjuvant chemotherapy (NACT) on immune activation in stage IIIC/IV tubo-ovarian high-grade serous carcinoma (HGSC), and its relationship to treatment response.

Journal details

Journal Clinical cancer research
Volume 22
Issue number 12
Pages 3025-3036
Available online
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Full text links

Publisher website (DOI) 10.1158/1078-0432.ccr-15-2657
Europe PubMed Central 27306793
Pubmed 27306793

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