Neural circuit assembly: economically wired by a single cadherin

Abstract

Neurons are thought to acquire shapes and configurations consistent with the wiring optimization principle. A new study sheds light on the underlying molecular mechanisms by demonstrating that N-cadherin-mediated differential adhesion determines relative neurite positioning in developing columnar synaptic modules.

Journal details

Journal Current Biology
Volume 24
Issue number 12
Pages R555-R557
Publication date

Keywords

Type of publication

Crick labs/facilities

Crick authors

Crick First author
Crick Corresponding author