Normal somatic mutations in cancer transformation


Gene alterations play a prominent role in driving cancer initiation and progression. However, the genetic events that occur in normal cells prior to tumorigenesis are still unknown. Recent studies have started to map somatic mutations in normal human tissues, and here we discuss their implications for our understanding of tumorigenesis.

Journal details

Journal Cancer Cell
Volume 39
Issue number 2
Pages 125-129
Available online
Publication date