Optimal age and outcome measures for Alzheimer's disease prevention trials in people with Down syndromeMore about Open Access at the Crick
Authors listR Hithersay RA Baksh CM Startin P Wijeratne S Hamburg B Carter The LonDownS Consortium A Strydom A Strydom E Fisher D Nizetic J Hardy Victor Tybulewicz A Karmiloff-Smith
Introduction: People with Down syndrome (DS) typically develop Alzheimer's disease (AD) neuropathology before age 40, but a lack of outcome measures and longitudinal data have impeded their inclusion in randomized controlled trials (RCTs). Methods: Cohort study. Event-based and dose-response Emax models were fitted to longitudinal cognitive data, to stage AD and determine the earliest ages of decline. Results informed sample size estimations for hypothetical RCTs of disease-modifying treatments that reduced decline by 35% or 75%. Results: Seventy-five percent of participants progressed or remained stable in the AD staging model; effect sizes varied by age group and tests. Varied treatment effects could be detected with 50-200 people per arm when using sensitive cognitive outcome measures and targeting recruitment to ages 36 to 45 years. Discussion: Efficient RCTs of AD preventative treatments can be conducted in the DS population using sensitive outcome measures to monitor early decline. Dose-response models could help tailor future RCTs.
Journal Alzheimer's and Dementia
Issue number 4