Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitorsMore about Open Access at the Crick
Authors listAdam M Thomas Sanja Brolih Joanna F McGouran Afaf H El-Sagheer Denis Ptchelkine Morgan Jones Neil McDonald Peter J McHugh Tom Brown
We report the design and optimisation of novel oligonucleotide substrates for a sensitive fluorescence assay for high-throughput screening and functional studies of the DNA repair enzyme, XPF-ERCC1, with a view to accelerating inhibitor and drug discovery.
Journal Chemical Communications
Issue number 78