Optogenetic control of morphogenesis goes 3D

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The generation of form in living embryos, a process termed “morphogenesis” from the Greek word μορφογένεση, is one of the most fascinating unsolved problems in biology. In embryonic epithelia, most attention has been paid to events occurring at the apical surface of epithelia, particularly the regulation of actomyosin contractility during morphogenetic change. In a new report, De Renzis and colleagues demonstrate a key role for regulated actomyosin contractility at the basal surface of the epithelium during formation of the first epithelial fold in (the “ventral furrow”) (Krueger , 2018).

Journal details

Journal EMBO Journal
Volume 37
Issue number 23
Pages e100961
Available online
Publication date

Crick labs/facilities