Overview of KRAS-driven genetically engineered mouse models of non-small cell lung cancer
Abstract
KRAS, the most frequently mutated oncogene in non-small cell lung cancer, has been utilized extensively to model human lung adenocarcinomas. The results from such studies have enhanced considerably an understanding of the relationship between KRAS and the development of lung cancer. Detailed in this overview are the features of various KRAS-driven genetically engineered mouse models (GEMMs) of non-small cell lung cancer, their utilization, and the potential of these models for the study of lung cancer biology.
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Volume 70
Issue number 1
Pages Unit 14.35
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Publisher website (DOI) 10.1002/0471141755.ph1435s70
Europe PubMed Central 26331885
Pubmed 26331885
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