p53 mutations in cancer


In the past fifteen years, it has become apparent that tumour-associated p53 mutations can provoke activities that are different to those resulting from simply loss of wild-type tumour-suppressing p53 function. Many of these mutant p53 proteins acquire oncogenic properties that enable them to promote invasion, metastasis, proliferation and cell survival. Here we highlight some of the emerging molecular mechanisms through which mutant p53 proteins can exert these oncogenic functions.

Journal details

Volume 15
Issue number 1
Pages 2-8
Publication date


Type of publication

Crick authors

Crick First author
Crick Corresponding author