Paligenosis: prepare to regenerate!
Abstract
Tissue injury can stimulate quiescent cells to proliferate, resulting in metaplasia, to rapidly replace damaged cells and enable regeneration. A new study describes how fully differentiated cells return to proliferation in an autophagy‐ and mTORC1‐dependent manner. Given the striking parallels between this process in mammalian stomach and pancreas, a new term, paligenosis, is proposed for this conserved program.
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Publisher website (DOI) 10.15252/embj.201899206
Europe PubMed Central 29567644
Pubmed 29567644
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