Phenotypic and functional profiling of CD4 T cell compartment in distinct populations of healthy adults with different antigenic exposure
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Sophie Roetynck Ally Olotu Joan Simam Kevin Marsh Brigitta Stockinger Britta Urban Jean LanghorneAbstract
Multiparameter flow cytometry has revealed extensive phenotypic and functional heterogeneity of CD4 T cell responses in mice and humans, emphasizing the importance of assessing multiple aspects of the immune response in correlation with infection or vaccination outcome. The aim of this study was to establish and validate reliable and feasible flow cytometry assays, which will allow us to characterize CD4 T cell population in humans in field studies more fully.
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Publisher website (DOI) 10.1371/journal.pone.0055195
Europe PubMed Central 23383106
Pubmed 23383106
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