PKC and the control of localized signal dynamics
Authors list
Carine Rosse Mark Linch Stéphanie Kermorgant Angus JM Cameron Katrina Boeckeler Peter ParkerAbstract
Networks of signal transducers determine the conversion of environmental cues into cellular actions. Among the main players in these networks are protein kinases, which can acutely and reversibly modify protein functions to influence cellular events. One group of kinases, the protein kinase C (PKC) family, have been increasingly implicated in the organization of signal propagation, particularly in the spatial distribution of signals. Examples of where and how various PKC isoforms direct this tier of signal organization are becoming more evident.
Journal details
Volume 11
Issue number 2
Pages 103-112
Publication date
Full text links
Publisher website (DOI) 10.1038/nrm2847
Europe PubMed Central 20094051
Pubmed 20094051
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