Plasmodium peekaboo: PK4 mediates parasite latency

Abstract

In this issue of Cell Host & Microbe, Zhang et al. (2017) show that translational repression through eIF2α phosphorylation mediated by PK4 kinase activity plays a key role in artemisinin resistance in recrudescent malaria infections. Targeting this druggable process could extend the lifespan of current frontline treatments.

Journal details

Volume 22
Issue number 6
Pages 724-725
Publication date

Crick authors

Crick First author
Crick Corresponding author