Population tailored modification of tuberculosis specific interferon-gamma release assay

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Kata Horvati Szilvia Bősze Hannah P Gideon Bernadett Bacsa Tamás G Szabó Rene Goliath Molebogeng X Rangaka Ferenc Hudecz Robert Wilkinson Katalin Wilkinson
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Abstract

Blood-based Interferon-Gamma Release Assays (IGRA) identify Mycobacterium tuberculosis (MTB) sensitisation with increased specificity, but sensitivity remains impaired in human immunodeficiency virus (HIV) infected persons. The QuantiFERON-TB Gold In-Tube test contains peptide 38-55 of Rv2654c, based on data indicating differential recognition between tuberculosis patients and BCG vaccinated controls in Europe. We aimed to fine map the T cell response to Rv2654c with the view of improving sensitivity.

Journal details

Journal Journal of Infection
Volume 72
Issue number 2
Pages 179-188
Available online
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Publisher website (DOI) 10.1016/j.jinf.2015.10.012
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Europe PubMed Central 26632326
Pubmed 26632326

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