Population tailored modification of tuberculosis specific interferon-gamma release assayMore about Open Access at the Crick
Authors listKata Horvati Szilvia Bősze Hannah P Gideon Bernadett Bacsa Tamás G Szabó Rene Goliath Molebogeng X Rangaka Ferenc Hudecz Robert Wilkinson Katalin Wilkinson
Blood-based Interferon-Gamma Release Assays (IGRA) identify Mycobacterium tuberculosis (MTB) sensitisation with increased specificity, but sensitivity remains impaired in human immunodeficiency virus (HIV) infected persons. The QuantiFERON-TB Gold In-Tube test contains peptide 38-55 of Rv2654c, based on data indicating differential recognition between tuberculosis patients and BCG vaccinated controls in Europe. We aimed to fine map the T cell response to Rv2654c with the view of improving sensitivity.
Journal Journal of Infection
Issue number 2