Predicting cancer evolution for patient benefit: Renal cell carcinoma paradigm
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Evolutionary features of cancer have important clinical implications, but their evaluation in the clinic is currently limited. Here, we review current approaches to reconstruct tumour subclonal structure setting and discuss tumour sampling method and experimental design influence. We describe clear-cell renal cell carcinoma (ccRCC) as an exemplar for understanding and predicting cancer evolutionary dynamics. Finally, we discuss how understanding cancer evolution can benefit patients.
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Volume 1877
Issue number 5
Pages 188759
Available online
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Publisher website (DOI) 10.1016/j.bbcan.2022.188759
Europe PubMed Central 35835341
Pubmed 35835341
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