Preventing paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome in high-risk patients: protocol of a randomized placebo-controlled trial of prednisone (predART trial)More about Open Access at the Crick
Authors listCari Stek Charlotte Schutz Lisette Blumenthal Friedrich Thienemann Jozefien Buyze Christiana Nöstlinger Raffaella Ravinetto Edwin Wouters Robert Colebunders Gary Maartens Robert Wilkinson Lutgarde Lynen Graeme Meintjes
Early antiretroviral therapy (ART) initiation in patients diagnosed with HIV-associated tuberculosis (TB) reduces mortality among those with the lowest CD4 counts. At the same time, both early ART and a low CD4 count heighten the risk of paradoxical TB-associated immune reconstitution inflammatory syndrome (TB-IRIS). TB is common in patients starting ART in sub-Saharan Africa. Safe interventions that reduce the incidence or severity of TB-IRIS are needed. Prednisone has been shown to reduce symptoms and markers of inflammation when used to treat TB-IRIS.
Journal JMIR Research Protocols
Issue number 3