Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories
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Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. Although advances are being made towards earlier detection and the development of impactful targeted therapies and immunotherapies, the 5-year survival of patients with advanced disease is still below 20%. Effective cancer research relies on pre-clinical model systems that accurately reflect the evolutionary course of disease progression and mimic patient responses to therapy. Here, we review pre-clinical models, including genetically engineered mouse models and patient-derived materials, such as cell lines, primary cell cultures, explant cultures and xenografts, that are currently being used to interrogate NSCLC evolution from pre-invasive disease through locally invasive cancer to the metastatic colonization of distant organ sites.
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Journal Open Biology
Volume 11
Issue number 1
Pages 200247
Available online
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Publisher website (DOI) 10.1098/rsob.200247
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Europe PubMed Central 33435818
Pubmed 33435818
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