Protein structures, folds and fold spaces

Abstract

There has been considerable progress towards the goal of understanding the space of possible tertiary structures adopted by proteins. Despite a greatly increased rate of structure determination and a deliberate strategy of sequencing proteins expected to be very different from those already known, it is now rare to see a genuinely new fold, leading to the conclusion that we have seen the majority of natural structural types. The increase in knowledge has also led to a critical examination of traditional fold-based classifications and their meaning for evolution and protein structures. We review these issues and discuss possible solutions.

Journal details

Volume 22
Issue number 3
Pages 033103
Publication date

Keywords

Type of publication

Crick labs/facilities