Protein structures, folds and fold spaces
Authors list
Michael I Sadowski William R TaylorAbstract
There has been considerable progress towards the goal of understanding the space of possible tertiary structures adopted by proteins. Despite a greatly increased rate of structure determination and a deliberate strategy of sequencing proteins expected to be very different from those already known, it is now rare to see a genuinely new fold, leading to the conclusion that we have seen the majority of natural structural types. The increase in knowledge has also led to a critical examination of traditional fold-based classifications and their meaning for evolution and protein structures. We review these issues and discuss possible solutions.
Journal details
Volume 22
Issue number 3
Pages 033103
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Publisher website (DOI) 10.1088/0953-8984/22/3/033103
Europe PubMed Central 21386276
Pubmed 21386276
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