pUBLically unzipping Parkin: how phosphorylation exposes a ligase bit by bitMore about Open Access at the Crick
Authors listKatja K Dove Rachel E Klevit Katrin Rittinger
Disposal of damaged mitochondria is tightly controlled by auto-inhibition mechanisms that keep the ubiquitin ligase Parkin in check. Several new structural studies provide insight into how PINK1-dependent phosphorylation of ubiquitin and Parkin may progressively relieve Parkin auto-inhibition.
Journal EMBO Journal
Issue number 20