Quality control: Maintaining molecular order and preventing cellular chaos
Authors listSonya Neal Fumiaki Ohtake Ana Maria Cuervo Ramanujan S Hegde Ursula Jakob Michael Lazarou Wendy V Gilbert Zhijian J Chen Sharon Tooze James E Haber Kylie J Walters F Ulrich Hartl
We asked experts from different fields-from genome maintenance and proteostasis to organelle degradation via ubiquitin and autophagy-"What does quality control mean to you?" Despite their diverse backgrounds, they converge on and discuss the importance of continuous quality control at all levels, context, communication, timing, decisions on whether to repair or remove, and the significance of dysregulated quality control in disease.
Journal Mol Cell
Issue number 8