Quantification of tumour evolution and heterogeneity via Bayesian epiallele detectionMore about Open Access at the Crick
Authors listJames E Barrett Andrew Feber Javier Herrero Miljana Tanic Gareth A Wilson Charles Swanton Stephan Beck
Epigenetic heterogeneity within a tumour can play an important role in tumour evolution and the emergence of resistance to treatment. It is increasingly recognised that the study of DNA methylation (DNAm) patterns along the genome - so-called 'epialleles' - offers greater insight into epigenetic dynamics than conventional analyses which examine DNAm marks individually.
Journal BMC Bioinformatics
Issue number 1