Quinoxaline-based inhibitors of malarial protease PfSUB1

Abstract

2,3-Bis(phenylamino)quinoxalines have been identified as a novel class of malarial protease PfSUB1 inhibitors by screening of Malaria Box compounds. The synthesis of analog series and investigation of their inhibitory activity provided preliminary structure-activity relationship to create in silico models for binding of these compounds into the active site of PfSUB1.

Journal details

Volume 50
Issue number 10
Pages 1457-1463
Available online
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Crick First author
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