Reducing prostaglandin E2 production to raise cancer immunogenicity

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Cyclooxygenases (COX), commonly upregulated in numerous cancers, generate prostaglandin E2 (PGE2), which has been implicated in key aspects of malignant growth including proliferation, invasion and angiogenesis. Recently, we showed that production of PGE2 by cancer cells dominantly enables progressive tumor growth via immune escape and that cyclooxygenase inhibitors synergize with immunotherapy to enhance tumor eradication.

Journal details

Journal Oncoimmunology
Volume 5
Issue number 5
Pages e1123370
Publication date