Regulating the regulator: Bhlhe40 directly keeps IL-10 in check

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Abstract

In this issue of , two complementary manuscripts by Huynh et al. (https://doi.org/10.1084/jem.20171704) and Yu et al. (https://doi.org/10.1084/jem.20170155) demonstrate that the transcription factor Bhlhe40 acts as a repressor of IL-10 production during infection with or Deletion of Bhlhe40 in both cases resulted in chronic infection and increased pathogen load as a consequence of increased IL-10 production.

Journal details

Volume 215
Issue number 7
Pages 1767-1769
Publication date