Regulating the regulator: Bhlhe40 directly keeps IL-10 in checkMore about Open Access at the Crick
In this issue of , two complementary manuscripts by Huynh et al. (https://doi.org/10.1084/jem.20171704) and Yu et al. (https://doi.org/10.1084/jem.20170155) demonstrate that the transcription factor Bhlhe40 acts as a repressor of IL-10 production during infection with or Deletion of Bhlhe40 in both cases resulted in chronic infection and increased pathogen load as a consequence of increased IL-10 production.
Journal Journal of Experimental Medicine
Issue number 7