Regulating the regulator: Bhlhe40 directly keeps IL-10 in check

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In this issue of , two complementary manuscripts by Huynh et al. ( and Yu et al. ( demonstrate that the transcription factor Bhlhe40 acts as a repressor of IL-10 production during infection with or Deletion of Bhlhe40 in both cases resulted in chronic infection and increased pathogen load as a consequence of increased IL-10 production.

Journal details

Volume 215
Issue number 7
Pages 1767-1769
Available online
Publication date