Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5ʹ splice site strength
Authors listVihandha O Wickramasinghe Mar Gonzàlez-Porta David Perera Arthur R Bartolozzi Christopher R Sibley Martina Hallegger Jernej Ule John C Marioni Ashok R Venkitaraman
Sequential assembly of the human spliceosome on RNA transcripts regulates splicing across the human transcriptome. The core spliceosome component PRPF8 is essential for spliceosome assembly through its participation in ribonucleoprotein (RNP) complexes for splice-site recognition, branch-point formation and catalysis. PRPF8 deficiency is linked to human diseases like retinitis pigmentosa or myeloid neoplasia, but its genome-wide effects on constitutive and alternative splicing remain unclear.
Journal Genome Biology
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Publisher website (DOI) 10.1186/s13059-015-0749-3
Europe PubMed Central 26392272
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