Regulation of processive motion and microtubule localization of cytoplasmic dynein
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Rupam Jha Thomas SurreyAbstract
The cytoplasmic dynein complex is the major minus-end-directed microtubule motor. Although its directionality is evolutionary well conserved, differences exist among cytoplasmic dyneins from different species in their stepping behaviour, maximum velocity and force production. Recent experiments also suggest differences in processivity regulation. In the present article, we give an overview of dynein's motile properties, with a special emphasis on processivity and its regulation. Furthermore, we summarize recent findings of different pathways for microtubule plus-end loading of dynein. The present review highlights how distinct functions in different cell types or organisms appear to require different mechanochemical dynein properties and localization pathways.
Journal details
Journal Biochemical Society Transactions
Volume 43
Issue number 1
Pages 48-57
Publication date
Full text links
Publisher website (DOI) 10.1042/bst20140252
Europe PubMed Central 25619245
Pubmed 25619245
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