Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer
Authors list
Rebecca Roylance David Endesfelder Patricia Gorman Rebecca A Burrell Jil Sander Ian Tomlinson Andrew M Hanby Valerie Speirs Andrea L Richardson Nicolai Birkbak Aron C Eklund Julian Downward Maik Kschischo Zoltan Szallasi Charles SwantonAbstract
Chromosomal instability (CIN) is thought to be associated with poor prognosis in solid tumors; however, evidence from preclinical and mouse tumor models suggest that CIN may paradoxically enhance or impair cancer cell fitness. Breast cancer prognostic expression signature sets, which reflect tumor CIN status, efficiently delineate outcome in estrogen receptor ER-positive breast cancer in contrast to ER-negative breast cancer, suggesting that the relationship of CIN with prognosis differs in these two breast cancer subtypes.
Journal details
Volume 20
Issue number 10
Pages 2183-2194
Publication date
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Publisher website (DOI) 10.1158/1055-9965.epi-11-0343
Europe PubMed Central 21784954
Pubmed 21784954
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