Repeated clinical malaria episodes are associated with modification of the immune system in children
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Yaw Bediako Rhys Adams Adam J Reid John Joseph Valletta Francis M Ndungu Jan Sodenkamp Jedidah Mwacharo Joyce Mwongeli Ngoi Domtila Kimani Oscar Kai Juliana Wambua George Nyangweso Etienne P de Villiers Mandy Sanders Magda Ewa Lotkowska Jing-Wen Lin Sarah Manni John WG Addy Mario Recker Chris Newbold Matthew Berriman Philip Bejon Kevin Marsh Jean LanghorneAbstract
There are over 200 million reported cases of malaria each year, and most children living in endemic areas will experience multiple episodes of clinical disease before puberty. We set out to understand how frequent clinical malaria, which elicits a strong inflammatory response, affects the immune system and whether these modifications are observable in the absence of detectable parasitaemia.
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Publisher website (DOI) 10.1186/s12916-019-1292-y
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Europe PubMed Central 30862316
Pubmed 30862316
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