Repeated clinical malaria episodes are associated with modification of the immune system in children

Journal Article: BMC MedicineYear Published: (2019) Volume Number: 17, Article Number: 60

Authors

Bediako, Yaw; Adams, Rhys; Reid, Adam J.; Valletta, John Joseph; Ndungu, Francis M.; Sodenkamp, Jan; Mwacharo, Jedidah; Ngoi, Joyce Mwongeli; Kimani, Domtila; Kai, Oscar; Wambua, Juliana; Nyangweso, George; de Villiers, Etienne P.; Sanders, Mandy; Lotkowska, Magda Ewa; Lin, Jing-Wen; Manni, Sarah; Addy, John W. G.; Recker, Mario; Newbold, Chris; Berriman, Matthew; Bejon, Philip; Marsh, Kevin; Langhorne, Jean

There are over 200 million reported cases of malaria each year, and most children living in endemic areas will experience multiple episodes of clinical disease before puberty. We set out to understand how frequent clinical malaria, which elicits a strong inflammatory response, affects the immune system and whether these modifications are observable in the absence of detectable parasitaemia.