The influence of neuronal differentiation
Guerrero et al., Development, 146, decv176297 (2019)
A study from James Briscoe has used simulations of the developing neural tube that model the cellular mechanics and dynamics to provide insight into how proliferation and differentiation affect tissue growth.
How HIV develops drug resistance
Cook et al., Nature, 367, 806-810 (2020)
The mechanism behind how HIV develops resistance to a widely-prescribed group of drugs has been uncovered by new research from the Crick and Dana-Farber Cancer Institute, with the findings opening the door to the development of more effective treatments.
Read the full news story.
Cryo-EM explains how cells prepare for DNA replication
Miller et al. Nature, 575, 704-710 (2019)
3i Project - a genetic resource for immunology
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation
Abeler-Dörner et al., Nature Immunology, 21, 26-100 (2020)
A large collaborative project, led by Adrian Hayday, has developed an immunophenotyping platform with high-throughput genetic screening. This community resource provides an improved understanding of immune variation in health and disease, and proposed better ways to monitor it. It also identified scores of immunoregulatory genes that were never previously implicated in immunology.
Two genes slow down the development of intestinal tumours
NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor
Novellasdemunt et al., The EMBO Journal, 39, e102771 (2020)
Benign intestinal tumours with mutations that delete or inactivate two particular tumour-suppressing genes develop more quickly towards cancerous forms, according to new research from Vivian Li's group.
Read the full news story.
Comparing the membrane lipidome
Delineating the rules for structural adaptation of membrane-associated proteins to evolutionary changes in membrane lipidome
Makarova et al., Current Biology, 30, 367-380.e8
New research from Snezhka Oliferenko's group has found that different membrane lipid compositions in two sister yeast species may be at the root of remarkable differences in fundamental membrane-centered processes.
New software suite accelerates proteomics: DIA-NN
DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput
Demichev et al., Nature Methods, 17, 41-44 (2020)
A paper from Markus Ralser's group describes a new, easy-to-use suite of software algorithms they have developed, which exploits deep neural networks for faster and more precise proteomic experiments.
New insights into ubiquitin transfer inhibitors
Single-domain antibodies as crystallization chaperones to enable structure-based inhibitor development for RBR E3 ubiquitin ligases
Tsai et al., Cell Chemical Biology, 27, 83-93.e9 (2020)
Research from Katrin Rittinger's lab in collaboration with GlaxoSmithKline, identifies new tools that provide insight into the mechanism of ubiquitin transfer by an E3 ligase and facilitate its crystallization and thus helps to develop structure-based inhibitors.
How immune cells extract antigens
Roper et al., eLife, 48093 (2019)
Tumour-associated loss of p53
Blaigh et al., Cell Reports, 30, 481-496.e6 (2020)
Research led by Karen Vousden's group has shown that cancer-specific loss of p53, a tumour suppressor, promotes immune tolerance through the recruitment of myeloid and Treg populations within the tumour microenvironment.