Resonance assignment of human LARP4A La module
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Isabel Cruz-Gallardo Luigi Martino Roberta Trotta Stefano De Tito Geoff Kelly R Andrew Atkinson Antonio Randazzo Maria R ConteAbstract
Human LARP4A belongs to a superfamily of RNA binding proteins called La-related proteins (LARPs). Whilst being a positive regulator of protein synthesis and a promoter of mRNA stability, LARP4A also controls cell morphology and motility in human breast and prostate cancer cells. All LARPs share a characteristic RNA binding unit named the La-module, which despite a high level of primary structure conservation exhibits a great versatility in RNA target selection. Human LARP4A La-module is the most divergent compared with other LARPs and its RNA recognition properties have only recently started to be revealed. Given the key role of LARP4A protein in cancer cell biology, we have initiated a complete NMR characterisation of its La-module and here we report the assignment of H, N and C resonances resulting from our studies.
Journal details
Journal Biomolecular NMR Assignments
Volume 13
Issue number 1
Pages 169-172
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Publisher website (DOI) 10.1007/s12104-019-09871-4
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Europe PubMed Central 30632004
Pubmed 30632004
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