Response to comment on "Circadian rhythms in the absence of the clock gene Bmal1"


Abruzzi et al argue that transcriptome oscillations found in our study in the absence of Bmal1 are of low amplitude, statistical significance, and consistency. However, their conclusions rely solely on a different statistical algorithm than we used. We provide statistical measures and additional analyses showing that our original analyses and observations are accurate. Further, we highlight independent lines of evidence indicating Bmal1-independent 24-hour molecular oscillations.

Journal details

Journal Science
Volume 372
Issue number 6539
Pages eabf1941
Available online
Publication date

Crick labs/facilities