Sensing of cell death by myeloid C-type lectin receptors
Abstract
Molecules associated with dead or dying cells can be detected by receptors on macrophages and dendritic cells. Signals from these receptors impact myeloid cell function and play a role in determining whether death is silent or proinflammatory, tolerogenic or immunogenic. Prominent among myeloid receptors detecting dead cells are C-type lectin receptors (CLRs). Signals from these receptors variably induce endocytosis of cell corpses, corpse degradation, retrieval of dead cell-associated antigens and/or modulation of immune responses. The sensing of tissue damage by myeloid CLRs complements detection of pathogens in immunity and represents an ancient response aimed at restoring tissue homeostasis.
Journal details
Journal Current Opinion in Immunology
Volume 25
Issue number 1
Pages 46-52
Publication date
Full text links
Publisher website (DOI) 10.1016/j.coi.2012.12.007
Europe PubMed Central 23332826
Pubmed 23332826
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