Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA
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MC Liu GR Oxnard EA Klein Charles Swanton MV Seiden CCGA Consortium Steven R Cummings Farnaz Absalan Gregory Alexander Brian Allen Hamed Amini Alexander M Aravanis Siddhartha Bagaria Leila Bazargan John F Beausang Jennifer Berman Craig Betts Alexander Blocker Joerg Bredno Robert Calef Gordon Cann Jeremy Carter Christopher Chang Hemanshi Chawla Xiaoji Chen Tom C Chien Daniel Civello Konstantin Davydov Vasiliki Demas Mohini Desai Zhao Dong Saniya Fayzullina Alexander P Fields Darya Filippova Peter Freese Eric T Fung Sante Gnerre Samuel Gross Meredith Halks-Miller Megan P Hall Anne-Renee Hartman Chenlu Hou Earl Hubbell Nathan Hunkapiller Karthik Jagadeesh Arash Jamshidi Roger Jiang Byoungsok Jung TaeHyung Kim Richard D Klausner Kathryn N Kurtzman Mark Lee Wendy Lin Jafi Lipson Hai Liu Qinwen Liu Margarita Lopatin Tara Maddala M Cyrus Maher Collin Melton Andrea Mich Shivani Nautiyal Jonathan Newman Joshua Newman Virgil Nicula Cosmos Nicolaou Ongjen Nikolic Wenying Pan Shilpen Patel Sarah A Prins Richard Rava Neda Ronaghi Onur Sakarya Ravi Vijaya Satya Jan Schellenberger Eric Scott Amy J Sehnert Rita Shaknovich Avinash Shanmugam KC Shashidhar Ling Shen Archana Shenoy Seyedmehdi Shojaee Pranav Singh Kristan K Steffen Susan Tang Jonathan M Toung Anton Valouev Oliver Venn Richard T Williams Tony Wu Hui H Xu Christopher Yakym Xiao Yang Jessica Yecies Alexander S Yip Jack Youngren Jeanne Yue Jingyang Zhang Lily Zhang Lori Quan Zhang Nan Zhang Christina Curtis Donald A Berry Toggle all authors (104)
Abstract
Early cancer detection could identify tumors at a time when outcomes are superior and treatment is less morbid. This prospective case-control sub-study (from NCT02889978 and NCT03085888) assessed the performance of targeted methylation analysis of circulating cell-free DNA (cfDNA) to detect and localize multiple cancer types across all stages at high specificity.
Journal details
Journal Annals of Oncology
Volume 31
Issue number 6
Pages 745-759
Available online
Publication date
Full text links
Publisher website (DOI) 10.1016/j.annonc.2020.02.011
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Europe PubMed Central 33506766
Pubmed 33506766