Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

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Early cancer detection could identify tumors at a time when outcomes are superior and treatment is less morbid. This prospective case-control sub-study (from NCT02889978 and NCT03085888) assessed the performance of targeted methylation analysis of circulating cell-free DNA (cfDNA) to detect and localize multiple cancer types across all stages at high specificity.

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Volume 31
Issue number 6
Pages 745-759
Available online
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