Silent' mitral cells dominate odor responses in the olfactory bulb of awake mice
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How wakefulness shapes neural activity is a topic of intense discussion. In the awake olfactory bulb, high activity with weak sensory-evoked responses has been reported in mitral/tufted cells (M/TCs). Using blind whole-cell recordings, we found 33% of M/TCs to be 'silent', yet still show strong sensory responses, with weak or inhibitory responses in 'active' neurons. Thus, a previously missed M/TC subpopulation can exert powerful influence over the olfactory bulb.
Journal details
Journal Nature Neuroscience
Volume 17
Issue number 10
Pages 1313-1315
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Publisher website (DOI) 10.1038/nn.3768
Europe PubMed Central 25064849
Pubmed 25064849
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