Single cell biology-a Keystone Symposia report
Authors list
Jennifer Cable Michael B Elowitz Ana I Domingos Naomi Habib Shalev Itzkovitz Homaira Hamidzada Michael S Balzer Itai Yanai Prisca Liberali Jessica Whited Aaron Streets Long Cai Andrew B Stergachis Clarice Kit Yee Hong Leeat Keren Martin Guilliams Uri Alon Alex K Shalek Regan Hamel Sarah J Pfau Arjun Raj Stephen R Quake Nancy R Zhang Jean Fan Cole Trapnell Bo Wang Noah F Greenwald Roser Vento-Tormo Silvia Santos Sabrina L Spencer Hernan G Garcia Geethika Arekatla Federico Gaiti Rinat Arbel-Goren Steffen Rulands Jan Philipp Junker Allon M Klein Samantha A Morris John I Murray Kate E Galloway Michael Ratz Merrit Romeike Toggle all authors (42)
Abstract
Single cell biology has the potential to elucidate many critical biological processes and diseases, from development and regeneration to cancer. Single cell analyses are uncovering the molecular diversity of cells, revealing a clearer picture of the variation among and between different cell types. New techniques are beginning to unravel how differences in cell state-transcriptional, epigenetic, and other characteristics-can lead to different cell fates among genetically identical cells, which underlies complex processes such as embryonic development, drug resistance, response to injury, and cellular reprogramming. Single cell technologies also pose significant challenges relating to processing and analyzing vast amounts of data collected. To realize the potential of single cell technologies, new computational approaches are needed. On March 17-19, 2021, experts in single cell biology met virtually for the Keystone eSymposium "Single Cell Biology" to discuss advances both in single cell applications and technologies.
Journal details
Volume 1506
Issue number 1
Pages 74-97
Available online
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Publisher website (DOI) 10.1111/nyas.14692
Europe PubMed Central 34605044
Pubmed 34605044
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