Six host-range restricted poxviruses from three genera induce distinct gene expression profiles in an in vivo mouse model

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Host-range restricted poxviruses make promising vaccine vectors due to their safety profile and immunogenicity. An understanding of the host innate immune responses produced by different poxvirus vectors would aid in the assessment, selection and rational design of improved vaccines for human and veterinary applications. Novel avipoxviruses are being assessed to determine if they are different from other poxvirus vectors. Analysis of the transcriptome induced in a mouse model would aid in determining if there were significant differences between different poxvirus vectors which may reflect different adjuvant potential as well as establish if they should be further evaluated as vaccine vectors.

Journal details

Journal BMC Genomics
Volume 16
Pages 510
Available online
Publication date

Crick authors

Crick First author
Crick Corresponding author