Smoothened sensor places sodium and sterols center stage

Abstract

Regulation of Smoothened by PTCH1 is central to Hedgehog signal transduction. Reporting recently in PNAS, Myers et al. (2017) provide evidence that a transmembrane flux of sodium ions drives PTCH1 activity and that cholesterol regulates Smoothened via its transmembrane domain.

Journal details

Volume 44
Issue number 1
Pages 3-4
Publication date