Smoothened sensor places sodium and sterols center stage


Regulation of Smoothened by PTCH1 is central to Hedgehog signal transduction. Reporting recently in PNAS, Myers et al. (2017) provide evidence that a transmembrane flux of sodium ions drives PTCH1 activity and that cholesterol regulates Smoothened via its transmembrane domain.

Journal details

Volume 44
Issue number 1
Pages 3-4
Publication date