Smoothened sensor places sodium and sterols center stage
Abstract
Regulation of Smoothened by PTCH1 is central to Hedgehog signal transduction. Reporting recently in PNAS, Myers et al. (2017) provide evidence that a transmembrane flux of sodium ions drives PTCH1 activity and that cholesterol regulates Smoothened via its transmembrane domain.
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Publisher website (DOI) 10.1016/j.devcel.2017.12.015
Europe PubMed Central 29316438
Pubmed 29316438
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