SnapShot: Cancer-associated fibroblasts

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Danielle Park Erik Sahai Toni Rullan Iriarte
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Abstract

Cancer-associated fibroblasts (CAFs) are an integral component of the tumor microenvironment and have both tumor-promoting and tumor-suppressive functions. This SnapShot summarizes the origins of CAFs, their diverse functions, and how this relates to heterogeneity within the population. The suitability of targeting CAFs therapeutically is also discussed.

Journal details

Journal Cell
Volume 181
Issue number 2
Pages 486-486.e1
Publication date

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Publisher website (DOI) 10.1016/j.cell.2020.03.013
Europe PubMed Central 32302576
Pubmed 32302576

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