Somatic TP53 mutations are detectable in circulating tumor DNA from children with anaplastic Wilms tumors
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Taryn D Treger Tasnim Chagtai Robert Butcher George D Cresswell Reem Al-Saadi Jesper Brok Richard D Williams Chrissy Roberts Nicholas Luscombe Kathy Pritchard Jones William MifsudAbstract
Diffuse anaplastic Wilms tumor (DAWT) is a rare, high-risk subtype that is often missed on diagnostic needle biopsy. Somatic mutations in TP53 are associated with the development of anaplasia and with poorer survival, particularly in advanced-stage disease. Early identification of DAWT harboring TP53 abnormalities could improve risk stratification of initial therapy and monitoring for recurrence.
Journal details
Journal Translational Oncology
Volume 11
Issue number 6
Pages 1301-1306
Available online
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Publisher website (DOI) 10.1016/j.tranon.2018.08.006
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Europe PubMed Central 30172241
Pubmed 30172241
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