Somatic TP53 mutations are detectable in circulating tumor DNA from children with anaplastic Wilms tumors

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Diffuse anaplastic Wilms tumor (DAWT) is a rare, high-risk subtype that is often missed on diagnostic needle biopsy. Somatic mutations in TP53 are associated with the development of anaplasia and with poorer survival, particularly in advanced-stage disease. Early identification of DAWT harboring TP53 abnormalities could improve risk stratification of initial therapy and monitoring for recurrence.

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Volume 11
Issue number 6
Pages 1301-1306
Available online
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Crick labs/facilities

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Crick First author
Crick Corresponding author