Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
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Beatrice Griffiths Caroline A Lewis Karim Bensaad Susana Ros Qifeng Zhang Emma C Ferber Sofia Konisti Barrie Peck Heike Miess Phil East Michael Wakelam Adrian L Harris Almut SchulzeAbstract
Regulation of lipid metabolism via activation of sterol regulatory element binding proteins (SREBPs) has emerged as an important function of the Akt/mTORC1 signaling axis. Although the contribution of dysregulated Akt/mTORC1 signaling to cancer has been investigated extensively and altered lipid metabolism is observed in many tumors, the exact role of SREBPs in the control of biosynthetic processes required for Akt-dependent cell growth and their contribution to tumorigenesis remains unclear.
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Publisher website (DOI) 10.1186/2049-3002-1-3
Europe PubMed Central 24280005
Pubmed 24280005
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