Sticking together the Crumbs - an unexpected function for an old friend
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Barry J Thompson Franck Pichaud Katja RöperAbstract
Cell polarity and cell-cell junctions have pivotal roles in organizing cells into tissues and in mediating cell-cell communication. The transmembrane protein Crumbs has a well-established role in the maintenance of epithelial polarity, and it can also regulate signalling via the Notch and Hippo pathways to influence tissue growth. The functions of Crumbs in epithelial polarity and Hippo-mediated growth depend on its short intracellular domain. Recent evidence now points to a conserved and fundamental role for the extracellular domain of Crumbs in mediating homophilic Crumbs-Crumbs interactions at cell-cell junctions.
Journal details
Volume 14
Issue number 5
Pages 307-314
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Publisher website (DOI) 10.1038/nrm3568
Europe PubMed Central 23609509
Pubmed 23609509
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