Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2
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Antoni Wrobel Donald Benton Pengqi Xu Lesley Calder Annabel Borg Chloe Roustan Stephen R Martin Peter Rosenthal John J Skehel Steve GamblinAbstract
Coronaviruses of bats and pangolins have been implicated in the origin and evolution of the pandemic SARS-CoV-2. We show that spikes from Guangdong Pangolin-CoVs, closely related to SARS-CoV-2, bind strongly to human and pangolin ACE2 receptors. We also report the cryo-EM structure of a Pangolin-CoV spike protein and show it adopts a fully-closed conformation and that, aside from the Receptor-Binding Domain, it resembles the spike of a bat coronavirus RaTG13 more than that of SARS-CoV-2.
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Journal Nature Communications
Volume 12
Issue number 1
Pages 837
Available online
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Publisher website (DOI) 10.1038/s41467-021-21006-9
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Europe PubMed Central 33547281
Pubmed 33547281
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