Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2More about Open Access at the Crick
Authors listAntoni Wrobel Donald Benton Pengqi Xu Lesley Calder Annabel Borg Chloe Roustan Stephen R Martin Peter Rosenthal John J Skehel Steve Gamblin
Coronaviruses of bats and pangolins have been implicated in the origin and evolution of the pandemic SARS-CoV-2. We show that spikes from Guangdong Pangolin-CoVs, closely related to SARS-CoV-2, bind strongly to human and pangolin ACE2 receptors. We also report the cryo-EM structure of a Pangolin-CoV spike protein and show it adopts a fully-closed conformation and that, aside from the Receptor-Binding Domain, it resembles the spike of a bat coronavirus RaTG13 more than that of SARS-CoV-2.
Journal Nature Communications
Issue number 1