Synovial sarcoma mechanisms: a series of unfortunate events


Human synovial sarcoma is caused by a chromosome translocation, which fuses DNA encoding SSX to that encoding the SS18 protein. Kadoch and Crabtree now show that the resulting cellular transformation stems from disruption of the normal architecture and function of the human SWI/SNF (BAF) complex.

Journal details

Journal Cell
Volume 153
Issue number 1
Pages 11-12
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