T cell control of malaria pathogenesis
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Philip J Spence Jean LanghorneAbstract
Transmission of Plasmodium from mosquito to the mammalian host leads to a clinically silent pre-erythrocytic stage of malaria infection, and subsequent cyclical erythrocytic invasion associated with disease. Recent evidence demonstrates that it is the interplay between CD4+ and CD8+ T cells, and the regulation of their response, throughout infection that dictates immunity and the pathogenesis of malaria. The elicited T cell response is context dependent, influenced by diverse host and parasite factors, necessitating the development of a unifying model of T cell potential during Plasmodium infection. Only then can we predict their capacity to dictate the outcome of human disease.
Journal details
Journal Current Opinion in Immunology
Volume 24
Issue number 4
Pages 444-448
Publication date
Full text links
Publisher website (DOI) 10.1016/j.coi.2012.05.003
Europe PubMed Central 22658628
Pubmed 22658628
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