T-cell/histiocyte-rich large B-cell lymphoma shows transcriptional features suggestive of a tolerogenic host immune response
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Peter Van Loo Thomas Tousseyn Vera Vanhentenrijk Daan Dierickx Agnieszka Malecka Isabelle Vanden Bempt Gregor Verhoef Jan Delabie Peter Marynen Patrick Matthys Chris De Wolf-PeetersAbstract
Gene expression profiling has successfully identified the prognostic significance of the host response in lymphomas. The aggressive T-cell/histiocyte-rich large B-cell lymphoma and the indolent nodular lymphocyte-predominant Hodgkin's lymphoma are both characterized by a paucity of tumor cells embedded in an overwhelming background. The tumor cells of both lymphomas share several characteristics, while the cellular composition of their microenvironment is clearly different.
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Publisher website (DOI) 10.3324/haematol.2009.009647
Europe PubMed Central 19797726
Pubmed 19797726
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